Understanding Semaglutide Dosing
Semaglutide requires a gradual titration schedule to minimize side effects and allow your body to adjust. This guide covers the complete dosing progression from start to maintenance.
Standard Titration Schedule
The FDA-approved titration for weight management (Wegovy):
| Weeks | Weekly Dose | Purpose |
|---|---|---|
| 1-4 | 0.25mg | Introduction |
| 5-8 | 0.5mg | Building tolerance |
| 9-12 | 1.0mg | Therapeutic dosing begins |
| 13-16 | 1.7mg | Approaching maintenance |
| 17+ | 2.4mg | Maintenance dose |
Reconstitution for Different Doses
If using compounded semaglutide, here are common reconstitution calculations:
For 5mg Vial
| BAC Water | Concentration | 0.25mg Dose | 0.5mg Dose |
|---|---|---|---|
| 2mL | 2.5mg/mL | 10 units | 20 units |
| 2.5mL | 2mg/mL | 12.5 units | 25 units |
For 10mg Vial
| BAC Water | Concentration | 0.5mg Dose | 1.0mg Dose |
|---|---|---|---|
| 2mL | 5mg/mL | 10 units | 20 units |
| 4mL | 2.5mg/mL | 20 units | 40 units |
When to Inject
- Frequency: Once weekly on the same day
- Timing: Any time of day, with or without food
- Consistency: Choose a day and stick to it (e.g., every Sunday)
Missed Dose Guidelines
- If less than 5 days late: Take the dose as soon as remembered
- If more than 5 days late: Skip and take next scheduled dose
- Never double up doses
Managing Side Effects During Titration
Side effects are most common during dose increases. Strategies to minimize:
- Eat smaller, more frequent meals
- Avoid high-fat and greasy foods
- Stay well hydrated
- Eat slowly and stop when satisfied
- Consider extending time at each dose level if needed
Extended Titration Option
If side effects are problematic, some protocols allow slower titration:
- Stay at each dose for 6 weeks instead of 4
- Add intermediate doses (0.75mg, 1.25mg)
- Consult with your healthcare provider about adjustments
Calculate Your Exact Dose
Use our Semaglutide Calculator to determine exactly how many units to draw based on your reconstitution and target dose.