NAD+

A cellular coenzyme central to energy production, declining with age.

What it is

NAD+ is not a peptide. It is a coenzyme present in every cell, required for the reactions that turn food into usable energy and for the repair enzymes that maintain DNA.

How it works

Levels fall with age. Supplementation aims to restore the pool that sirtuins and PARP enzymes draw on, which is the basis of most longevity interest.

What it is researched for

• Energy and fatigue
• Cognitive clarity
• Metabolic and cellular ageing markers

Research status

Human research is early. Oral precursors such as NMN and NR have more published data.

What to watch for

• Flushing, nausea, and chest tightness when infused or injected quickly
• Painful injections, which is the most common complaint
• Slow administration reduces most of the discomfort

Storage

Refrigerate. Protect from light.

Common questions

Why do people say the injection hurts?

NAD+ is acidic and is often injected in a large volume. Going slowly and reducing the dose helps.

Is oral NMN the same thing?

It is a precursor. The body converts it to NAD+, with lower and slower delivery than injection.

Educational reference only, not medical advice.