Tesamorelin

The GHRH analogue with human trial data on visceral belly fat.

What it is

Tesamorelin is a stabilised form of growth hormone releasing hormone, approved in the US for a specific condition involving excess visceral fat.

How it works

It raises endogenous growth hormone and IGF-1, which shifts how the body handles stored fat around the organs rather than under the skin.

What it is researched for

• Visceral fat reduction
• Liver fat
• Cognitive measures in older adults

Research status

FDA approved for HIV-associated lipodystrophy. Other uses are off label or research.

What to watch for

• Joint aches and swelling
• Raised blood sugar in some users
• Costly compared with other GH secretagogues

Storage

Lyophilised powder keeps in the freezer or fridge, away from light. Once reconstituted with bacteriostatic water, keep it refrigerated and use it within about four weeks.

Common questions

Does it work on regular body fat?

Published trials measured deep visceral fat. Effects on subcutaneous fat were much smaller.

Why dose at night?

It follows the body own GH rhythm, which peaks in early sleep.

Educational reference only, not medical advice.